"It is only the the 'run as admin' in shortcuts that does not work."
- Sounds like the developers\publishers of the software have too restrictive requirements if they require you to
use the main .exe every time you launch the program.
Or are they only demanding you use the main .exe with Compatibility set to 'run as admin' as a one time only part of
the programs activation ?
Whatever the case. This is not a Windows issue. It's something they need to address.
The requirement to run it as administrator was only for registering the software. And, anyway, I was able to do so by drilling down through the shortcuts to the actual .exe file and "right-click->run as admin" worked there just fine.
How is this not a Windows issue? I think you may have misunderstood: The "run as admin" shortcuts for ANY program in Start or on the Desktop do not work. I have no reason to believe that the newly installed program caused the problem, and the software's odd requirement only revealed the shortcut issue.