Hi and thanks for reaching out. My name is William. I'm a Windows technical expert. I'll be happy to help you out today.
You can try to fix by created the required path in C:\Windows\System32\config\systemprofile\desktop. You will need to be an administrator. Just use file explorer to navigate as far as you can into the path and create the required subfolder until you have the entire path and restart.
Note, the path is C:\Windows\System32, not C:\Windows\system as you eluded to in your post.