Hello turkoyuncutr102,
I'm John an Independent Advisor and a Microsoft user like you. I'll be happy to assist you today. I understand you want to know if its safe to delete the contents for Software Distribution folder.
The answer is Yes. The Software Distribution folder is a vital component for Windows Update, which temporarily stores files needed to install new updates. It's safe to clear the content of the said folder because Windows 10 will always re-download and re-created all the necessary file and components, if removed. We always did this as a troubleshooting method if we're having trouble with Windows update.
Kindly let me know if this helps or if you have any further concerns.
Sincerely
John DeV
Independent Advisor