Hi and thanks for reaching out. My name is William, I’m an Independent Advisor. I'll be happy to help you out today.
For the most part, ASLR may introduce instability or dysfunctionality for programs executables that do not explicitly participate in using this feature, especially portable programs (so-called self-contained exes). Latest MS documentation (https://docs.microsoft.com/en-us/windows/securi...) includes this warning as well:
Warning
Some security mitigation technologies may have compatibility issues with some applications. You should test exploit protection in all target use scenarios by using audit mode before deploying the configuration across a production environment or the rest of your network.
For more details, this may help with some of the technical aspects: https://msrc-blog.microsoft.com/2017/11/21/clar...