Morning from Wisconsin
First, I'm no expert.
At anything.
So I offer no advice.
I just wanted to share my personal experience.
I hope it is of some little help to you.
The answer to your question is yes.
How do I know ?
Cuz that's what I do on my Win 10 Laptop. (Been doing it for years.)
I run WIn 10 Home version 20H2 (OS Build 19042.685).
I use Google drive for my cloud storage.
The first thing I needed to do was map a drive letter on my laptop that pointed to my Google drive cloud storage.
(I choose "G:". Original huh ?)
Once this mapping had been completed, all the apps on my laptop access my Google drive via the drive letter I assigned and they can't tell the difference between an actual local drive and my cloud storage.
This goes for not only backup apps but office applications such as Word, Excel as well as others.
I use the Macrium Reflect product to create images of my laptop.
And it allows me to choose my "G" drive without issue.
I am not aware of any way to create this mapping natively.
So, I needed to download an app to my laptop that was designed to do exactly that.
There are a number of these apps available on the Internet.
Some are free and some you need to pay for.
I use a free app named "RailDrive Standard Edition".
Here's a link to a video that explains the process for a paid version of this kind of app.
https://www.youtube.com/watch?v=q4TxjbGY6f8
It's worth watching.
Good luck to you.