Nobody wants to believe this when I say it, but it's quite possible that your computer has been successfully taken over by a third party who is using your computer to do work on their behalf.
The nature of attacks on consumer computers has evolved over the years. Today, the professionals who do these things for a living are not really interested in anything you have on your computer (unless you make it easy for them.) They're much more interested in joining hundreds and even thousands of computers together in what's called a botnet, to use by themselves or to rent to others to crack passwords, perform encryption and decryption, forward torrents and launch attacks on other computers. One of the telltale signs of such activity is that for no apparent reason, a hard drive fills with seemingly meaningless files that may be visible or hidden.
Typical antivirus software is not going to notice this, because your computer is not being attacked. No harm is being done to your computer and the nature of the work your computer is doing are activities that computers commonly do.
I'm not saying that for sure your computer has been compromised, but what you're seeing is what typically happens when a computer has been successfully attacked in this way, so it's something you should at least consider.
One rough test you can run is to take your computer off the internet and off your local network - unplug it from everything. If the activity stops, that's probably because the attacker can no longer reach your computer to send it instructions or collect data.