Disk Cleanup is safe to use. It won't delete personal data, or uninstall programs\apps, and you can clear the tic box next stuff
you may not want to be cleaned.
How much RAM do you have total ? Windows will easily use 3.5+ GB system RAM at idle with the basic background processes
and a small number of apps\programs enabled in the Startup tab.
I have 4.2GB 'in use' atm (the term 'in use' should be viewed loosly on Win10. 'Populated' may be more accurate) with only one browser
and two tabs open.
I don't have Office 365, but see that MC Teams is part of that software. If you don't need the Teams option you may be able to
disable it via Windows Services, and if you don't use Office 365 regularly you can disable that in Startup and launch it manually
when needed.
Whatever the case, Win10 manages RAM more efficiently than previous versions of Windows, which means it will cache more data
(populate all that RAM that's just sitting there looking pretty), but if you are not using Office365 at a time that something else requires more RAM,
Windows will (should) reallocate space for whatever you have running in the foreground.
If you are a heavy multi-tasker you may want to install more RAM to keep things running smoothly.
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