Hi Ari94
I am Dave, an Independent Advisor, I will help you with this . . .
1
If you are intending to use that USB Flash drive for storing data like Images and Videos, you should use NTFS, because FAT32 have an upper file size limit and NTFS is more efficient
2
If you want to create a Windows 10 Bootable USB on that Flash Drive, you should use the Media Creation Tool to create that Media, the process is automatic, and no need to select a format, the tool will do that for you
3
If you want to use Rufus to create a bootable Windows 10 USB, then the Format to choose is NTFS with a cluster size of 4096 Bytes