How to Upgrade Exchange 2016 (CU21) to New (CU22) Step by Step Details required

It’s recommended to update the Exchange Server in the lab environment before updating it in the production environment.

1 - Download Cumulative Update CU22 for Exchange Server 2016 (KB5005333)
2 - Update to Microsoft .NET Framework 4.8
3 - Install Cumulative Update Exchange 2016

Cumulative Update CU22 for Exchange Server 2016 is released as version 15.01.2375.007. Which version are you running now? Read more on how to find your Exchange version build number.

In multidomain Active Directory forests in which Exchange is installed or has been prepared previously by using the /PrepareDomain option in Setup, this action must be completed after the /PrepareAD command for this Cumulative Update has been completed and the changes are replicated to all domains. Setup will try to run the /PrepareAD command during the first server installation. Installation will finish only if the user who initiated Setup has the appropriate permissions.

Hi @Sathishkumar Singh

The official document here provides the detailed steps to perform the upgrade operation.

Upgrade Exchange to the latest Cumulative Update

Get the latest version of Exchange 2016, download and install Cumulative Update 22 for Exchange Server 2016

The account that you'll use to install the CU requires membership in the Exchange Organization Management role group. If the CU requires Active Directory schema updates or domain preparation, the account will likely require additional permissions. (Prepare Active Directory and domains for Exchange Server)
Verify the target server meets the potentially new system requirements and prerequisites for the CU

Note: Any customized Exchange or Internet Information Server (IIS) settings that you made in Exchange XML application configuration files on the Exchange server (for example, web.config files or the EdgeTransport.exe.config file) will be overwritten when you install an Exchange CU. Be sure save this information so you can easily re-apply the settings after the install. After you install the Exchange CU, you need to re-configure these settings.

Then you could Install an Exchange CU using the Setup wizard

Or using unattended Setup from the command line
For example:

E:\Setup.exe /IAcceptExchangeServerLicenseTerms_DiagnosticDataON /Mode:Upgrade /DomainController:dc01.contoso.com  

In addition, this official tool Exchange Deployment Assistant will be helpful when you deploy your environment, you could have a try.

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