I've been having the exact same issue here. Have you managed to sort it? I am going crazy and have tried about a hundred different things, nothing works. Ever since 20H2, my AMD graphics drivers just will not work.
More info:
Windows: 10 20H2
CPU: AMD Ryzen 3600
GPU: AMD RX 570
No matter what, my Device Manager > Display Adapter > Properties > Events shows Device: amddwdmg not started (when using latest driver from AMD directly) or amdkmdap not started (when using latest driver available from Windows Update). Here is a copy of what the summarised Event log says about it:
Device PCI\VEN_1002&DEV_67DF&SUBSYS_C5701682&REV_EF\4&1fc990d7&0&0019 had a problem starting.
Driver Name: oem0.inf
Class Guid: {4d36e968-e325-11ce-bfc1-08002be10318}
Service: amdwddmg
Lower Filters:
Upper Filters:
Problem: 0x0
Problem Status: 0xC00000E5
I've tried the latest drivers (Radeon 21.5.2). I've tried every driver before, going back to 21.3.2. I've tried completely removing the drivers before installing different ones with both DDU and AMD Clean-up Tool, on separate occasions (both in safe mode). I've tried even removing AMD Adrenalin software and just using the safe Windows 10 AMD driver (26.20.15002.61) instead of the latest one, without Adrenalin installed. I've tried removing Afterburner. I've tried sfc/scannow. No matter what, the result is the same. Either amdkmdap fails to start, or amdwddmg fails to start.
No, My GPU is not currently overclocked. It had a safe, stable undervolted overclock prior to this issue arising, but temps never got above 80 degrees Celcius (yes, that's how overly-safe I am with this computer). Of course, this was reset to default once I noticed that suddenly I couldn't play some games properly. Every time I installed a new driver, this was again reset to default.
Strangely, Resident Evil 2 wasn't really affected much by this, however AC Odyssey will not work for more than 2 minutes, since this issue started arising. I had been playing RE2 with this issue in the background without even realising it had been going on. I only realised I was having issues when went back to AC Odyssey for the first time in a month or two and suddenly couldn't play. (Yes, I did also try reinstalling Odyssey just in case).
If anyone has any ideas about what on earth is going on, please feel free to help. I am all out of ideas.