Other Configuration Manager-related features and issues
It might because the IIS in Windows Server turns on HTTP/2 by default and only falls back to the older HTTP/1.1 if the browser doesn’t support HTTP/2.
First, you can disable the weaker cipher suites, which is recommended for security purposes, and leave HTTP/2 enabled. The second option is to disable HTTP/2 in IIS and only use the older HTTP/1.1 standard.
For the reference:
https://www.tecklyfe.com/how-to-fix-ns_error_net_inadequate_security-and-err_spdy_inadequate_transport_security-in-iis-on-windows-server-2016/
(Please note: Information posted in the given link is hosted by a third party. Microsoft does not guarantee the accuracy and effectiveness of information.)
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