Good Day Paul,
My name is Carlo, I'm an Independent Advisor and community member like you.
I am also using Windows 10 pc. Let us work together to sort this out.
First, try to plug those readers using another computer for us to check if the issue is with your computer or those readers itself.
-If the card reader cannot be detected using other device means they are faulty, try to use other cable.
If the card reader can be detected using other computer , please proceed with the steps below.
-Press Windows key + X
-Go to Device Manager
-Expand the Universal Bus Controller
-Look for USB 3.0 Extensible Host Controller and USB 3.0 Root Hub
-Right click and Uninstall them both
After restart the driver will be automatically installed.
Restart your computer and try to connect the card readers, you can also try with a different ports.
Have a wonderful day ahead and stay safe.
Sincerely,
Carlo T.