Something is clearly wrong with your system, since there's no way a Windows Defender Quick scan should ever scan more than about 30 to 40,000 files, while yours is indicating it's already scanned over 366,000.
I've never seen this particular symptom before, though we occasionally hear about extremely long scan times.
If someone else here knows a way to reset only Windows Defender, then that might aid in removing the problem, but otherwise I'd think only resetting or otherwise repairing Windows 10 itself might be the solution required.
Rob
I agree with Rob.
Here are two procedures that may reset Defender, and aid in resolving your problem.
Less trouble than rebuilding your complete OS.
Copy the following PowerShell Cmdlet.
Get-AppxPackage *SecHealthUI* -allusers | foreach {Add-AppxPackage -DisableDevelopmentMode -Register "$($_.InstallLocation)\AppxManifest.xml"}
Then open Windows PowerShell (Admin) by right clicking the Windows Logo (Start Key), and
select it. On the PowerShell screen, right click on the blinking System 32 cursor, and the Cmdlet
will populate. If it doesn't start automatically, hit <enter>.
The procedure does not run for very long. You can tell that it is running by the green bar with
the yellow writing. When it finishes, type exit, at the cursor and restart your PC. Test the Quick
Scan again. If this did not offer relief, you can try the manual reset that is within Defender.
Scroll down the "Start" menu to "Windows Security", and right click it.
Rest the cursor on "More", and click "App Settings".
Scroll down to "Reset" and click that. This deletes the App's data.
Restart your PC, and test Quick Scan again.
Good luck, Glen