Hi Friendly,
Defender will not function properly as your Real-Time antivirus program, if another program
is installed. If you want to use McAfee for your real-time protection, you will need to turn on
"Periodic Scanning" in Defender. That places Defender into passive mode. In that mode, it can
be used for scans, but it will not supply real-time protection.
You can find the Periodic Scanning switch on the Virus & Threat Protection screen. Scroll down
to find "Microsoft Defender Antivirus Options" and select it. Turn the switch to "ON" to allow
Defender to function with McAfee installed.
Glen