Hi Prathmesh,
If you uninstall that port, Windows will just re-install it, if you right click that device, select Properties and select the driver tab, do you have the option to just disable that device?
If not, because that is an internal hub on your motherboard, check in BIOS, if there is an option to disable that USB Port.
Another option would be to update your chipset drivers from the support page for your PC on the manufacturers website.