Hi ECa. I'm Greg, 10 years awarded Windows MVP, here to help you.
- If it works in Safe Mode and not Windows that usually means it's a driver. Do you have the Chipset and BIOS fully updated from the PC or motherboard manufacturer's Support Downloads webpage for your exact model?
Compare the latest drivers with the ones presently installed in Device Manager reached by right clicking the Start Menu. Make sure you have the latest BIOS, Chipset, Display (Video), Sound, USB3, Bluetooth, Network and all other drivers, or else download and install the latest now.
- If no newer or this doesn't help, then go to the USB category in Device Manager, open each Enhanced, Hub and Host controller, from Driver tab select Roll back if available, or if not choose Uninstall.
If your keyboard and mouse are USB, first program the power button to effect the needed restart after Rolling back or uninstalling the driver. Go to Settings > System > Power & Sleep > Additional Power Settings > Choose what Power buttons do to choose Shutdown.
Finally open the USB controller drivers, from Driver tab choose Update Driver, then Automatically. If that doesn't help then choose Update Driver > Browse > Let Me Pick to try all previously installed drivers queued there.
- Try all the steps here for USB ports not working in Windows 11:
https://www.guidingtech.com/top-ways-to-fix-win...
https://windowsreport.com/windows-11-not-recogn...
(Avoid ad links which intrude into editorial copy, especially avoid Restoro, PC Repair Tool and Reimage ads)
https://www.groovypost.com/howto/fix-usb-not-wo...
https://www.youtube.com/watch?v=V9RX5Z8AxRU
https://www.youtube.com/watch?v=0fp5dkrmbNo
- Establish a Clean Boot to turn off Startup Freeloaders that can conflict and cause issues:
https://www.makeuseof.com/clean-boot-windows-11/
- Download, install and run a full scan with free Malwarebyes from https://www.malwarebytes.com/mwb-download/ after enabling Root Kit scan in Scan Settings. Clean Up anything it finds and then run again. Turn off Real Time trial in Control panel to keep as on-demand scanner.
- Run System File Checker/DISM in WIndows 11 to find and fix any broken System files:
https://www.elevenforum.com/t/use-system-file-c...
- If that doesn't fix it then you can do a Windows 11 Repair Upgrade which reinstalls Windows while saving your files and apps in place, brings it up to the latest version by the most stable method, takes about an hour and resolves most problems: https://www.elevenforum.com/t/repair-install-wi...
Feel free to ask back any questions. Based on the results you post back I may have other suggestions if necessary.
______________________________________________
Standard Disclaimer: There are links to non-Microsoft websites. The pages appear to be providing accurate, safe information. Watch out for ads on the sites that may advertise products frequently classified as a PUP (Potentially Unwanted Products). Thoroughly research any product advertised on the sites before you decide to download and install it.