I apologize that i am writing using machine translation.
I too have suffered from this problem for several years, 95% of my games and apps like Bluestacks would not launch and I was also worried about damage to my hardware as I could not shut down and reboot without forcing the power off. But I finally discovered the cause today!
When this problem starts, the game seems to stop the process during the launch process (loading dlls, etc.). So I tried using ProcessMonitor, thinking that if I could find the last dll that was trying to load, it might help solve the problem.
https://learn.microsoft.com/ja-jp/sysinternals/downloads/procmon
Then I found that it stopped after loading the "xinput" dll file... Yes, I always have an Xbox360 (very old) controller plugged into my PC. I pulled it out and plugged it in. My games are now up and running!