Hi, I’m Nicole, I’ll be happy to help you out today.
Nope, you can't directly delete that folder since that is an integral part of the Windows operating system in which temporary files are stored. However, you can delete all items inside the folder since they are temporary files only.
You can use the disk cleanup utility of Windows to free up some space.
Right-click on Local Disk C then click properties.
Next, click disk cleanup.
Next, clean up system files.
Next, check all items that consume space there then click ok to start the disk cleanup.
After the disk cleanup, you should have free some space on your drive.
Regards.