Hello! My name is Cristiano. I'm an Independent Advisor. I'm glad to help you.
Try this: press the control key or stand still and not touch anything else for a few seconds, which may make the left click work again.
Another solution is to clean your mouse or try a different USB port.
It's also possible that the issue is due to a hardware failure, in which case you may need to replace your mouse.
Additionally, some games may have specific settings that affect mouse functionality, so it's worth checking the game's settings to see if there's a fix there.