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Hi Dryer,
I'm Sumit, here to answer your query at the Microsoft Community.
This is a catch-22 situation that was first reported in April and continuing as far as I know. Riot Games need to fix it.
As of now, there isn't a solution available for the issue at hand. It is now up to Riot to ensure that Vanguard is compliant with the necessary security requirements. If you wish to have Vanguard installed and enabled, you will have to disable KM Hardware-enforced stack protection. However, this may lead to a decrease in the overall security of your Windows installation. It's not as unsafe as disabling the firewall or antivirus, but it's a choice that must be considered.
Hope that helps, and rely on us for any further inquiries. All the best.