I have this same issue on a Dell XPS 9575 2in1 running Windows 11 Pro. Unfortunately, I have used this laptop exclusively with a Bluetooth mouse and keyboard for a long time and can't say when this issue first began.
At the moment, neither the keyboard nor the touchpad are working. I have two I2C HID drivers showing, the second of which has failed and reports, "This device cannot start. (Code 10) A request for the HID descriptor failed." I have endlessly searched forums for a solution to this problem. I have, at times, been able to get them both working, but then they stop. Sometimes, I can get the keyboard working. Both of these devices always work perfectly when in the bios.
Dell claims the touchpad driver for this device comes from Microsoft; thus, they are no help.
I noticed the issue when I installed a new hard drive and attempted a fresh install of Windows 11. Both the keyboard and touchpad quit after installation. I performed all updates and installed all drivers. Nothing worked. I reformatted the drive and tried several more times before giving up, using Dell's full install recovery image, and returning to Windows 10 Pro. Neither the keyboard nor the touchpad worked. I then began winding back bios updates; I jumped back three bios updates with no change.
At this point, I went back to the previous hard drive, and everything worked. I cloned the hard drive to the new hard drive and swapped them. The clone drive worked FOR A DAY.
All hardware troubleshooters reported the hardware was fine. Dell claims there are no new drivers to be installed.
The Dell Support Assistant also experiences erratic issues and will not start the Dell Client Management Service. If I uninstall and reinstall it, the local program works fine. If afterwards I log on to Dell support website (which draws on the client management service it will typically work once (if at all) after which neither the local program nor the web interface will work.
Windows has been configured not to install additional drivers, and yet it still does.
People have been having this problem for at least a year across different devices, yet I see very little in the way of resolution.