Hello, this is Emily.
Unless your device is assigned to you by work, it is not recommended to set up the computer using a work email account, because it requires your company to have Azure Active Directory set up in order to allow this to happen as well. It will then also subject your device to your company's group policy, meaning they can manage your computers Settings by requiring password policy, etc.
If you simply just want to separate work and personal use, you can perhaps use a local account instead. Hold down Windows + R keys, type in netplwiz and hit enter. When launched, click on Add. Then select the option that doesn't use Microsoft account. Then select local user. Once the user is made, double click on it and go to group membership tab to make it admin.
This way your personal Microsoft account apps and data won't be mixed into this user profile.