I see the same thing on Windows 11. It doesn't matter if I am using a USB 3.0 Powered HUB, USB 2.0 powered hub or the USB ports on the motherboard. This especially seems to happen if I am trying to copy large files from a USB device to my SATA drives, (SSD's). Sometimes it will reconnect on it's own and sometimes all USB device are non-responsive. When it happens if I try to plug in a USB flash drive - nothing it doesn't even acknowledge that I plugged it in. Once I do a complete shutdown the USB ports are responsive again. No I did not have this problem with Windows 10. All hardware and software with the exception of Windows 11 is EXACTLY the same. This doesn't impact my USB keyboard and wireless USB mouse for some reason, but they are plugged into a KVM, but nothing else works.
Please stop wasting our time with busy work and escalate this to development as this is CLEARLY a Windows 11 issue. All my drivers and updates are current.
Thank You
Gordon