These folders:
C:\Users\your user account\Desktop
C:\Users\your user account\Documents
C:\Users\your user account\Downloads
C:\Users\your user account\Music
C:\Users\your user account\Pictures
C:\Users\your user account\Videos
can, and should be moved from your C: drive to a different drive.
You can repartition your physical hard drive so that it contains two partitions (also known as 'logical drives') that will be your C: drive and your D: drive. But a better solution, if it's available to you, is to put your personal folders on a separate physical hard drive. Thus, your first physical hard drive is C: and your second physical hard drive is D:
If you are using the OneDrive app to sync those folders, I'm afraid everything becomes more complicated.
You can't simply move those folders. You have to designate their new location as the default location for those types of file. You can do this best with the Location tab, as Emily previously explained. For more details on how to do this the right way, just ask. One of us (or another volunteer) will gladly help you.
Separating your software and your personal folders on separate drives has important advantages beyond merely freeing up space on your C: drive. It means that you can backup and restore your software and your data on different schedules and with different software, if you choose.
BTW: The destination for your backups should always be somewhere outside your computer. An external hard drive (not a USB flash drive) is an excellent choice. So is Network Attached Storage, which is more expensive than an external hard drive because it incorporates extra features.