Hi Ravi Nelwade.
Welcome to Microsoft Community.
In your description, your computer's external USB mouse is not working.
I noticed that you tried connecting the mouse to another computer and tried the method of connecting the other mouse to the computer and installing the driver, thank you for your efforts to resolve this issue, I do understand the frustration and inconvenience of just having the mouse not working on your computer at this time.
We are also a little puzzled by the situation you describe, the problem could be related to a driver error, or a third party software conflict, but there is an additional possibility that there is some error in the system's registry that is causing the problem.
There are a few things we can do to determine the problem.
To rule out third-party software conflicts, I recommend trying a clean boot which starts Windows with a minimal set of drivers and startup programs. It can be used to determine whether a background service or program is interfering or causing a problem.
These steps of "clean boot" might look complicated at first glance. However, to avoid any trouble for you, please follow them in order and step-by-step.
Check to see if you can use an external USB mouse during clean boot.
In order to determine if it is driver related, you can refer to the following link to enter safe mode
Windows startup settings - Microsoft Support
See if you can use an external USB mouse in Safe Mode.
If none of the above steps allow you to use the external USB mouse, then the problem is most likely from the previously mentioned, possibly an error in the registry entry for the mouse.
You can try using a mouse with another connection, such as a Bluetooth mouse, to see if there is a problem with the other connection.
At the same time, you can refer to the following steps, in the registry to do some checks
1 Search for “Registry Editor” in the taskbar, right-click it, and select Open as Administrator.
2 Navigate to the following path
HKEY_LOCAL_MACHINE\SYSTEM\CurrentControlSet\Services\Mouse
Check if the value of Start in Mouse is 4.
Then navigate to the following path
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows\CurrentVersion\Policies\System
See if there are some policies that disable input devices or mice.
Also, please let me know your system details, you can search “System information” in the taskbar.
Please try the above methods and let me know the result, I will provide you further help according to your result.
Thank you for your understanding and support.
Best regards,
Zev - MSFT | Microsoft Community Support Specialist