Not sure if you were ever able to resolve this somewhere else, but I've also had a similar problem for the longest (~years), and poked at it every now and then without really getting much of anywhere and put it off again and again. I decided to poke at it a little more after reading this, and a few other things, and the it seems like it may be at least partially related to driver-side anti-aliasing. I stumbled on FXAA in my Nvidia Control Panel global 3D settings (I've had a 980 Ti for the longest), and after re-reading its tooltips for like the 50th time I disabled it (I usually flip it on along with adjusting a few other things when I clean install fresh drivers), and it seems to have dramatically reduced text blurring (I tested with my Outlook Calendar, which pretty quickly shows this blurring effect). I'm pretty sure there's still a bit of blurring going on, could be related to/resolvable by cleartext or whatever, but it's a ton less than before. I turned off MFAA afterward for good measure, too. Seems to have also eliminated video playback flickering (I've been getting it in Prime Video lately, but it's appeared elsewhere before, and I frustratedly ended up trying to workaround to other players, or just dealing with it by avoiding whichever window/screen with my mouse cursor while watching lol).
TLDR; Disable FXAA in your graphics card's global 3D settings. For Nvidia: Open Nvidia Control Panel -> Manage 3D settings -> Anti-aliasing FXAA - Off. Not sure if AMD has this issue, or how to get to it, but I doubt it's that different.
I'll have to see if it works out over the next couple of days, but it looks good so far.