Hello ER.
I'm Riza an Independent Advisor. Thank you for reaching out to the Microsoft Community.
To answer your question, yes, Windows is supports a global mic mute option through USB keyboards, especially with recent updates.
For Windows 11 users, Win + Alt + K is the official shortcut.
Important Note: Currently, this shortcut primarily works reliably with Microsoft Teams. Microsoft has indicated that third-party applications will gain support for this feature, but it's not universally implemented across all applications yet.
When this shortcut is used, you'll see a microphone icon in the system tray, indicating the mic's status.
For a more reliable global mute, Microsoft PowerToys with its Win + Shift + A shortcut is highly recommended. It includes a "Video Conference Mute" utility that provides a system-wide mic mute shortcut. This is generally more reliable for a global mute than the built-in Windows 11 shortcut, as it's designed to work across various applications.
PowerToys is a free suite of utilities from Microsoft, and you can download it from their official website.
If the above options don't fully meet your needs, or if you're on an older version of Windows, you can use third-party tools like AutoHotkey.
AutoHotkey allows you to create custom hotkeys and scripts to perform various actions, including toggling microphone mute. This gives you a high degree of customization and can be used to create a "global" mute where Windows might not natively offer one for a specific application.
Hope one of these will help.
Best Regards,
RizaP