Hi dimsoer,
Do you mean to set up your Office 365 account manually? If so, there’s no need to set up your account manually with Microsoft Exchange, because the auto-discover feature will acquire configuration for your Exchange account. Learn how to set up your Exchange account at https://support.office.com/en-us/article/add-an-email-account-to-outlook-6e27792a-9267-4aa4-8bb6-c84ef146101b.
If you want to set up your account manually via IMAP or POP3 protocol you may refer to https://support.office.com/en-us/article/add-an-email-account-using-advanced-setup-560a9065-3c3a-4ec5-a24f-cdb9a8d622a2#bkmk_advanced.
If this is not what you mean or if you have other questions, please elaborate question so that we can help you further.
Thanks,
Kevin