A family of Microsoft relational database management systems designed for ease of use.
I agree with John. Though I do have a sample HRIS app on my website (Disclaimer: it has not been updated for a while so it shows its age).
But when I built a an HRIS system for my current company, I started from scratch since its needs are different.
I definitely would not do it in Excel, since even the simplest requirements would want a relational database.
If you want to explain what you need this to do we can suggest some things.