Can't Turn Off Core Isolation/Memory Integrity

Question

I have a domain based computer that when reputation based security was turned it it enabled the Core Isolation/Memory Isolation turned on and there issue with Memory Isolation and drivers prevented video cards from starting for a number of my collegues for secondary monitors on their laptop. I went into GPO and turned the Virtualization setting back to not configured. I then restarted my machine. Core Isolation and Virtualization Based Security is still on. I went into my GPEdit and made sure the settings wasn't set. RSOP shows that nothing is enforcing it. I then went into the registry and set the keys to 0 to turn it of and reboot and it is still turned on. Even the easy way where I go in and flip the switch in Core Isolation to off and it restarts, it is still on.

Running Windows 10 (21H2) Professional x64 patched to the latest.

Has anyone else had this and why can't I get it to turn off to get everyone's video card to turn back on?

UPDATE: Have been able to turn reputation based security off but I still can't get Core Isolation/Memory Integrity off. If I flip the switch and reboot the switch turns itself back on. On reboot before login it says "Please Wait" for a longer amount of time than normal. I wonder if there is something there turning it back on.