Sounds like something is writing lots of files to your disk. Unfortunately we have no way of knowing what that process(es) is/are. To help you figure this out, if simply scanning the drive doesn't help, you'll need to use a disk space analyzer. It'll show you where all the files are coming from and from that you can look at the files to see who might be creating them. I don't use a DSA myself so here's a link to a third party site that has some recommendations. Bear in mind that some of its recommendations are probably paid ads.
If you cannot figure out, from the DSA results, which process is creating the files (looking at the create user is often helpful) then use a tool like Process Monitor to monitor calls to the file system to the directory(ies) that are filling up. It should tell you who is creating the files but it can easily generate overwhelming logs because of all the IO calls so you'll likely need to filter out "safe" apps like services.