
The SMTP Connect error 10060 indicates that there is a connectivity problem to your SMT P Server. You may need to check the connectivity between your server and SMTP host.
https://www.courier.com/error-solutions/smtp-connect-error-10060/
You may use telnet command from the SharePoint Server(s) to ensure that there is connectivity to SMTP Server.
https://learn.microsoft.com/en-us/exchange/mail-flow/test-smtp-telnet?view=exchserver-2019
https://www.comparitech.com/net-admin/telnet-smtp-test/
Hope this helps