Hello there,
It is not advised to do so. Domain-based namespaces do not support the use of failover clusters as namespace servers.
One of the quorum models for Failover Clustering is the ability to use a file share as a witness resource. As a recap, the File Share Witness is designated a vote in the Cluster when needed and can act as a tie breaker in case there is ever a split between nodes (mainly seen in multi-site scenarios).
However, over the years, we have seen where this share is put on a DFS Share. This is an awfully bad idea and one not supported by Microsoft.
More info here https://techcommunity.microsoft.com/t5/failover-clustering/failover-cluster-file-share-witness-and-dfs/ba-p/372147
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