Datawedge is the product that manage scanner on Zebra Devices
You should have a "Profile0" that is the default profile that manage all apps that does not have a dedicated profile.
You should have also a Datawege Demo. Does it works? (it works with profile "DataWedge Demo").
If Excel does not have a dedicated profile it should use Profile 0. Take a look in Profile 0 if the Keyboard wedge mode is enabled