Hi @wu chen ,
Welcome to Microsoft Q&A forum.
If you start your application by right-clicking it and choose run as administrator, will it work? Please try to navigate to the directories of those .pdb files and then right-click them > Properties > Security > Edit > and check to confirm that the related permissions have been set and assigned.
Besides, are those files blocked like following screenshot(file property page):
BTW, if there’s any permission limitation on your machine, please check and confirm that they don’t block these files from being opened.
Best Regards,
Tianyu
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