After KB5019964 installed on our two Server 2016 DCs, we were unable to logon using Windows authentication to our legacy SQL2000 on a Server 2003R2 server from domain Win7 or Win10 workstations, from multiple applications, including SSMS.
SSMS error was "Logon failed for user (null)...".
It was still possible to connect if SQL authentication was instead used.
Removing KB5019964 restored normal connectivity using Windows authentication.