I partially understood your answer, I'm still very new. I had debug showing but in the code I posted it showed zero problems though I will admit when it does show problems I only partially understand what it's telling me. It looks like my problem wasn't even what I thought it was, I thought it was not recognizing the characters "CI" in the Mjrtxt.Text textbox but it was, it was the way I had my If's and Else's laid out that it was skipping a chunk of my code all together. This is how I changed it to work exactly as I was trying.
Private Sub btnClick_Click(sender As Object, e As EventArgs) Handles btnClick.Click
Dim grTot As Integer
grTot = CDec(Grd1txt.Text) + CDec(Grd2txt.Text) + CDec(Grd3txt.Text)
Dim grAvg As Integer
grAvg = grTot / 3
If Mjrtxt.Text = "CI" Then
If grAvg > 70 Then
Statxt.Text = "Passing"
Else
Statxt.Text = "Failing"
End If
Else
Statxt.Text = "Not a CI major"
End If
End Sub