Hi SK,
please check:
HTTP 500 error when you connect to the Operations Manager web console
https://learn.microsoft.com/en-us/troubleshoot/system-center/scom/http-500-error-connecting-to-web-console?WT.mc_id=EM-MVP-5002219
"500 Internal Server Error" in SCOM 2016 Web Console
https://operations601.rssing.com/chan-15252729/article9988.html
TROUBLESHOOTING: SCOM WEB CONSOLE 500 – INTERNAL SERVER ERROR
http://www.opsconfig.com/troubleshooting-scom-web-console-500-internal-server-error/
Hope you will find a solution amongst those article.
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Regards
Stoyan Chalakov