Hi! You'll need to investigate the Hyper-V Host for possible reasons as the cause can vary. Please have a look at the event logs in Event Viewer on your Hyper-V host for clues for the NIC status change and plausible reason at the timestamp when your issue started. Look at the System Event Logs and the Hyper-V logs (Hyper-V-Worker, Hyper-V-VMMS, Hyper-V-VmSwitch).
And of course please note that Windows Server 2008 R2 has been out of support for many years, and it would be best for your guest workloads if you upgrade the OS version.