Hello Crib bar,
The main reasons to segregate different hardware, such as Desktops and Laptops, is usually the same as to separate Servers and Workstations. For one side, there is the hardware perspective, as you may want to enable some Registry configurations specific for some models. On the other hand, there may be specific GPO that apply to Laptop computers (such as encryption and other policies) that are not required in Desktops. Additionally, there may be additional security policies or application permissions for Laptop users due to mobility (first that comes in mind is to avoid connecting to unencrypted networks, for example)
Beside that, many sysadmins that are more specific, would create OU per department, and then sub-OU per users or computers, then another OU level for Desktops and Laptops. Depending on the extension and complexity of the organization structure this can be quite an advantage.
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