Hi Eudias Kifem,
I agree with Erland that the low version could be an issue. This means you may not have a new version of the fix package. And SQL Server 2018 R2 is no longer supported.
Upon reboot, connections are successful but this reoccurs exactly after 7days
At the beginning of the seven days windows an SQL authentication can be successful, right? If so, this is a bit unusual. Given that you've troubleshot SPN, you might want to check the Windows logs and pay your attention to the Error Level log.
By the way, SQL Server network protocols can be viewed in SQL Server Configuration Manager, and you can verify that your protocols are properly enabled.
Best regards,
Seeya
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