Hi @Joseph Larrew ,
I noticed that you have a large number of servers, are all servers updated to the latest version?
If you don't have any expired certificate on your system or any certificate that's about to expire, please follow these steps to remove the AsyncOperationNotification folder within the System mailbox to see if it can stop the Microsoft Exchange Services Host Service crashing:
1) The user will need to have full access to arbitration mailbox
a. Get-Mailbox -Arbitration "SystemMailbox{e0dc1c29-89c3-4034-b678-e6c29d823ed9}" | Add-MailboxPermission -User administrator -AccessRights FullAccess
2) Run the Script from Exchange Command Shell login as the user with full permission assigned to arbitration mailbox
3) Confirm all the messages are deleted
4) Start the service MSExchangeServiceHost and confirm that it is not Crashing
5) Revoke the full Access permission for the user
a. Get-Mailbox -Arbitration "SystemMailbox{e0dc1c29-89c3-4034-b678-e6c29d823ed9}" | Remove-MailboxPermission -User administrator -AccessRights FullAccess
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