Hi @Michael de Graaf ,
but get-hostedoutboundspamfilterpolicy commands return no data, and attempting to create a new policy fails.
Is there any error message when the new policy fails to be created?
Normally, membership in the "Organization Management" or "Security Administrator" role groups is sufficient for adding, modifying or deleting anti-spam policies, so it doesn't appear to be a permission issue in your case. See this official document about configure anti-spam policies, and comments in this similar thread. Have you by any chance made any changes into the role groups right prior to the occurrence of this issue?
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