Hi @SergiEE,
Yes, we can run SCCM 2012 r2 in Windows Server 2019. But also recommended that you could upgrade the SCCM to the latest version after the OS upgraded.
1, Some prerequisites of upgrade from Windows Server 2012 to Windows Server 2019, please refer to this link:
2, For how to upgrade it, this link for your reference:
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Looking forward to your feedback.
Best regards,
Cherry
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