With thanks to Christopher Edwards
I am actually using VBA and I have actually seen the same thing and I believe it is related to the Roaming Signatures feature that has now been rolled to 50% of Outlook 365 Desktops in the current build.. https://www.microsoft.com/en-us/microsoft-365/roadmap?filters=&searchterms=60371 There is also a reg fix at the top of this thread - https://techcommunity.microsoft.com/t5/outlook/outlook-roaming-signature-vs-signatures-on-this-device/m-p/3672866 More details here - https://support.microsoft.com/en-us/office/outlook-roaming-signatures-420c2995-1f57-4291-9004-8f6f97c54d15?ui=en-us&rs=en-us&ad=us