Not possible without routing through Office 365 for example and using rule-based connectors or 3rd party software such as :
Send connector for distribution list (Exchange on premise)
Is it possible to create a send connector (Exchange 2016 on premise) for specific distribution lists? Need to bypass the Barracuda spam filter (outbound) for specific lists only - when smart hosting through them external recipients do not receive the emails to the list, only internal recipients do. Thanks.
Exchange | Exchange Server | Management
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Andy David - MVP 157.8K Reputation points MVP Volunteer Moderator
2020-10-12T15:52:56.597+00:00 -
KyleXu-MSFT 26,396 Reputation points
2020-10-13T07:40:49.393+00:00 @Jack - ITP
The sender connector is selected by the recipients domain, it cannot only work for a part of users. Here is an article about Selecting the connector for an external recipient. It may be helpful to you.
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