Hi @Stephen Morrison ,
What version and Update Rollup of SCOM are you currently running?
Have you enabled TLS 1.2 for your SCOM environment?
How to implement Transport Layer Security 1.2
https://learn.microsoft.com/en-us/system-center/scom/plan-security-tls12-config?view=sc-om-2019
TLS 1.2 Protocol Support Deployment Guide for System Center 2016
https://support.microsoft.com/en-us/help/4051111/tls-1-2-protocol-support-deployment-guide-for-system-center-2016
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Best regards,
Leon