Yes, there is policy, if you navigate to:
Computer Configuration > Administrative Templates > Windows Components > Microsoft Defender Antivirus
And then select Turn off Microsoft Defender Antivirus and set it as Disabled and this disable the turn off option which mean it will be forced to be on and user couldn't turn it off.
Have a look at:
https://learn.microsoft.com/en-us/mem/intune/user-help/turn-on-defender-windows