A DataCenter license provides for unlimited hosting but does not provide unlimited activations of host product key. In order to make use of unlimited hosting you should install a DataCenter host and use AVMA activations. This also provides the benefit of allowing activation ranging from Server 2012 R2 to Server 2022 both editions.
When you use another hypervisor the only option is to reuse the product key over and over, but unlimited activations of the host product key is not possible and at some point you'll run out at which time you'll need to contact microsoft in order to reset the activations count.
--please don't forget to
Accept as answer if the reply is helpful--