Hi Louis,
What you could do is send the email address to your own REST API and it would check the address using one of the email validation services that can detect disposable addresses. If your service gets a result back that the address is fake/disposable, then you would return an error response which would block the sign-up.
It appears that below sample code be modified to do what you need:
https://github.com/azure-ad-b2c/rest-api
To find an API service that can detect disposable addresses, if you search the web for "email validation api service disposable" you will get multiple to choose from.
Please click Accept Answer if the above was useful.
Thanks.
-TP